The South Carolina State Museum is a comprehensive museum with exhibits in science, technology, history and the arts. It is the state's largest museum and one of the largest museums in the Southeast.

The Columbia Museum of Art features changing exhibits throughout the year. Located at the corner of Hampton and Main Streets, the museum offers amazing art, lectures, films and guided tours.

EdVenture is the South's largest children's museum. Its state-of-the-art facility is located next to the South Carolina State Museum on Gervais Street. This delightful museum allows children to explore and learn while having fun.

McKissick Museum is located on the University of South Carolina campus. The museum features changing exhibitions of art, science, regional history and folk art.

The Confederate Relic Room and Museum showcases a relic collection from the Colonial period to the space age. The museum houses a wonderful collection of relics from the South Carolina confederate period.

The Lexington County Museum provides guided tours of a 19th century farmhouse and its outbuildings. The museum depicts everyday life in pre-Civil War Lexington County.